Peer-Reviewed Studies

 

Macon EL, Harris P, McClendon M, Perron B, Adams A. Insulin dysregulated horses metabolic responses to forage pellets. J Equine Vet Sci. 2024 Feb;133:104991. doi: 10.1016/j.jevs.2023.104991. Epub 2023 Dec 29. PMID: 38159582.

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Macon EL, Harris P, Bailey S, Caldwell Barker A, Adams A. Identifying possible thresholds for nonstructural carbohydrates in the insulin dysregulated horse. Equine Vet J. 2023 Nov;55(6):1069-1077. doi: 10.1111/evj.13910. Epub 2023 Jan 23. Erratum in: Equine Vet J. 2024 Feb 27;: PMID: 36537847.

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Adams AA, Siard-Altman MH, Reedy SE, Barker D, Elzinga S, Sanz MG, Urschel K, Ireland JL. Evaluation of seasonal influences on adrenocorticotropic hormone response to the thyrotropin-releasing hormone stimulation test and its accuracy for diagnosis of pituitary pars intermedia dysfunction. Vet J. 2023 Oct-Dec;300-302:106035. doi: 10.1016/j.tvjl.2023.106035. Epub 2023 Oct 5. PMID: 37802466.

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Colmer SF, Adams AA, Adam E, Miller R, Stefanovski D, Kulp JC, van Eps A. The effect of pre-dosing with metformin on the insulin response to oral sugar in insulin-dysregulated horses. Equine Vet J. 2024 Mar;56(2):318-325. doi: 10.1111/evj.13979. Epub 2023 Aug 6. PMID: 37545128.

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Jacquay ET, Harris PA, Adams AA. Age-Related Differences in Short-Term Transportation Stress Responses of Horses. J Equine Vet Sci. 2023 Sep;128:104879. doi: 10.1016/j.jevs.2023.104879. Epub 2023 Jul 1. PMID: 37399910.

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Herbst AC, Coleman MC, Macon EL, Brokman A, Stromberg AJ, Harris PA, Adams AA. Retirement risk factors, exercise management and muscle mass in US senior horses. Equine Vet J. 2023 Jun 21. doi: 10.1111/evj.13958. Epub ahead of print. PMID: 37341387.

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Turner S, Knych HK, Adams AA. The effects of cannabidiol on immune function and health parameters in senior horses. Vet Immunol Immunopathol. 2023 Mar;257:110549. doi: 10.1016/j.vetimm.2023.110549. Epub 2023 Jan 19. PMID: 36682327.

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Christmann U, Page AE, Horohov DW, Adams AA, Chapman SE, Hancock CL, Emery AL, Poovey JR, Hagg C, Ortega Morales SM, Duncan AR, Morgan J, Couetil LL, Morresey P, Wood PL. Lipidomic analysis of surfactant and plasma from horses with asthma and age-matched healthy horses. Am J Vet Res. 2022 Jul 11;83(9):ajvr.21.11.0179. doi: 10.2460/ajvr.21.11.0179. PMID: 35895773.

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Turner SE, Knych HK, Adams AA. Pharmacokinetics of cannabidiol in a randomized crossover trial in senior horses. Am J Vet Res. 2022 Jul 18;83(9):ajvr.22.02.0028. doi: 10.2460/ajvr.22.02.0028. PMID: 35895770.

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Macon EL, Harris P, Barker VD, Adams AA. Seasonal Insulin Responses to the Oral Sugar Test in Healthy and Insulin Dysregulated Horses. J Equine Vet Sci. 2022 Apr 8;113:103945. doi: 10.1016/j.jevs.2022.103945. Epub ahead of print. PMID: 35405290.

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Herbst AC, Johnson MG, Gammons H, Reedy SE, Urschel KL, Harris PA, Adams AA. Development and Evaluation of a Muscle Atrophy Scoring System (MASS) for Horses. J Equine Vet Sci. 2022 Mar;110:103771. doi: 10.1016/j.jevs.2021.103771. Epub 2021 Sep 20. PMID: 34973594.

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Miller AB, Murphy BA, Adams AA. Impact of blue light therapy on plasma adrenocorticotropic hormone (ACTH) and hypertrichosis in horses with pituitary pars intermedia dysfunction. Domest Anim Endocrinol. 2022 Jan;78:106651. doi: 10.1016/j.domaniend.2021.106651. Epub 2021 Jul 27. PMID: 34656964.

 

Miller AB, Harris PA, Barker VD, Adams AA. Short-term transport stress and supplementation alter immune function in aged horses. PLoS One. 2021 Aug 19;16(8):e0254139. doi: 10.1371/journal.pone.0254139. PMID: 34411137; PMCID: PMC8376036.

 

Turner S, Barker VD, Adams AA. Effects of Cannabidiol on the In Vitro Lymphocyte Pro-Inflammatory Cytokine Production of Senior Horses. J Equine Vet Sci. 2021 Aug;103:103668. doi: 10.1016/j.jevs.2021.103668. Epub 2021 May 24. PMID: 34281647.

 

Miller AB, Loynachan AT, Barker VD, Adams AA. Investigation of innate immune function in adult and geriatric horses. Vet Immunol Immunopathol. 2021 May;235:110207. doi: 10.1016/j.vetimm.2021.110207. Epub 2021 Feb 12. PMID: 33735821.

 

Miller AB, Loynachan AT, Bush HM, Hart KA, Barker VD, Campana-Emard AG, Grubbs ST, Adams AA. Effects of pituitary pars intermedia dysfunction and Prascend (pergolide tablets) treatment on endocrine and immune function in horses. Domest Anim Endocrinol. 2021 Jan;74:106531. doi: 10.1016/j.domaniend.2020.106531. Epub 2020 Jul 29. PMID: 32942194.

 

Zak A, Siwinska N, Elzinga S, Barker VD, Stefaniak T, Schanbacher BJ, Place NJ, Niedzwiedz A, Adams AA. Effects of advanced age and pituitary pars intermedia dysfunction on components of the acute phase reaction in horses. Domest Anim Endocrinol. 2020 Jul;72:106476. doi: 10.1016/j.domaniend.2020.106476. Epub 2020 Mar 7. PMID: 32380311.

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Zak A, Siwinska N, Elzinga S, Barker VD, Stefaniak T, Schanbacher BJ, Place NJ, Niedzwiedz A, Adams AA. Effects of equine metabolic syndrome on inflammation and acute-phase markers in horses. Domest Anim Endocrinol. 2020 Jul;72:106448. doi: 10.1016/j.domaniend.2020.106448. Epub 2020 Feb 14. PMID: 32247989.

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Steuer AE, Stewart JC, Barker VD, Adams AA, Nielsen MK. Cytokine and goblet cell gene expression in equine cyathostomin infection and larvicidal anthelmintic therapy. Parasite Immunol. 2020 Jun;42(6):e12709. doi: 10.1111/pim.12709. Epub 2020 Mar 20. PMID: 32145074.

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Siard-Altman MH, Harris PA, Moffett-Krotky AD, Ireland JL, Betancourt A, Barker VD, McMurry KE, Reedy SE, Adams AA. Relationships of inflamm-aging with circulating nutrient levels, body composition, age, and pituitary pars intermedia dysfunction in a senior horse population. Vet Immunol Immunopathol. 2020 Mar;221:110013. doi: 10.1016/j.vetimm.2020.110013. Epub 2020 Jan 26. PMID: 32058159.

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Elzinga SE, Betancourt A, Stewart JC, Altman MH, Barker VD, Muholland M, Bailey S, Brennan KM, Adams AA. Effects of Docosahexaenoic Acid-Rich Microalgae Supplementation on Metabolic and Inflammatory Parameters in Horses With Equine Metabolic Syndrome. J Equine Vet Sci. 2019 Dec;83:102811. doi: 10.1016/j.jevs.2019.102811. Epub 2019 Oct 21. PMID: 31791524.

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Fedorka CE, Loux SL, Scoggin KE, Adams AA, Troedsson MHT, Ball BA. Alterations in T cell-related transcripts at the feto-maternal interface throughout equine gestation. Placenta. 2020 Jan 1;89:78-87. doi: 10.1016/j.placenta.2019.10.011. Epub 2019 Nov 2. PMID: 31730925.

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Loos CMM, Dorsch SC, Elzinga SE, Brewster-Barnes T, Vanzant ES, Adams AA, Urschel KL. A high protein meal affects plasma insulin concentrations and amino acid metabolism in horses with equine metabolic syndrome. Vet J. 2019 Sep;251:105341. doi: 10.1016/j.tvjl.2019.105341. Epub 2019 Jul 20. PMID: 31492392.

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Fedorka CE, Ball BA, Scoggin KE, Loux SC, Troedsson MHT, Adams AA. The feto-maternal immune response to equine placentitis. Am J Reprod Immunol. 2019 Nov;82(5):e13179. doi: 10.1111/aji.13179. Epub 2019 Aug 28. PMID: 31373743.

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Fedorka CE, Ball BA, Walker OF, Conley AJ, Corbin CJ, Lu KG, Hanneman JM, Troedsson MHT, Adams AA. Alteration of the mare's immune system by the synthetic progestin, altrenogest. Am J Reprod Immunol. 2019 Aug;82(2):e13145. doi: 10.1111/aji.13145. Epub 2019 Jun 4. PMID: 31087434.

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Elzinga S, Reedy S, Barker VD, Chambers TM, Adams AA. Humoral and cell-mediated immune responses to influenza vaccination in equine metabolic syndrome (EMS) horses. Vet Immunol Immunopathol. 2018 May;199:32-38. doi: 10.1016/j.vetimm.2018.03.009. Epub 2018 Mar 23. PMID: 29678227.

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Elzinga SE, Rohleder B, Schanbacher B, McQuerry K, Barker VD, Adams AA. Metabolic and inflammatory responses to the common sweetener stevioside and a glycemic challenge in horses with equine metabolic syndrome. Domest Anim Endocrinol. 2017 Jul;60:1-8. doi: 10.1016/j.domaniend.2017.01.001. Epub 2017 Feb 4. PMID: 28254632.

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Siard MH, McMurry KE, Adams AA. Effects of polyphenols including curcuminoids, resveratrol, quercetin, pterostilbene, and hydroxypterostilbene on lymphocyte pro-inflammatory cytokine production of senior horses in vitro. Vet Immunol Immunopathol. 2016 May;173:50-9. doi: 10.1016/j.vetimm.2016.04.001. Epub 2016 Apr 4. PMID: 27090627.

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Mastro LM, Adams AA, Urschel KL. Pituitary pars intermedia dysfunction does not necessarily impair insulin sensitivity in old horses. Domest Anim Endocrinol. 2015 Jan;50:14-25. doi: 10.1016/j.domaniend.2014.07.003. Epub 2014 Aug 1. PMID: 25240230.

 

Mastro LM, Adams AA, Urschel KL. Whole-body phenylalanine kinetics and skeletal muscle protein signaling in horses with pituitary pars intermedia dysfunction. Am J Vet Res. 2014 Jul;75(7):658-67. doi: 10.2460/ajvr.75.7.658. PMID: 24959733.

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Wagner AL, Urschel KL, Betancourt A, Adams AA, Horohov DW. Effects of advanced age on whole-body protein synthesis and skeletal muscle mechanistic target of rapamycin signaling in horses. Am J Vet Res. 2013 Nov;74(11):1433-42. doi: 10.2460/ajvr.74.11.1433. PMID: 24168310.

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Brummer M, Hayes S, Adams AA, Horohov DW, Dawson KA, Lawrence LM. The effect of selenium supplementation on vaccination response and immune function in adult horses. J Anim Sci. 2013 Aug;91(8):3702-15. doi: 10.2527/jas.2012-5819. Epub 2013 May 8. PMID: 23658361.

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Adams AA, Horohov DW. The effect of an immunomodulator (parapoxvirus ovis) on cell-mediated immunity (CMI) in abruptly weaned foals. Vet Immunol Immunopathol. 2013 May 15;153(1-2):118-22. doi: 10.1016/j.vetimm.2012.11.020. Epub 2012 Dec 13. PMID: 23312290.

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Sun L, Gong Z, Oberst EJ, Betancourt A, Adams AA, Horohov DW. The promoter region of interferon-gamma is hypermethylated in neonatal foals and its demethylation is associated with increased gene expression. Dev Comp Immunol. 2013 Mar;39(3):273-8. doi: 10.1016/j.dci.2012.09.006. Epub 2012 Oct 11. PMID: 23063468.

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Ault A, Zajac AM, Kong WP, Gorres JP, Royals M, Wei CJ, Bao S, Yang ZY, Reedy SE, Sturgill TL, Page AE, Donofrio-Newman J, Adams AA, Balasuriya UB, Horohov DW, Chambers TM, Nabel GJ, Rao SS. Immunogenicity and clinical protection against equine influenza by DNA vaccination of ponies. Vaccine. 2012 Jun 6;30(26):3965-74. doi: 10.1016/j.vaccine.2012.03.026. Epub 2012 Mar 23. PMID: 22449425; PMCID: PMC3474358.

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Sun L, Adams AA, Betancourt A, Stewart JC, Liu C, Horohov DW. The role of proliferation in the regulation of interferon gamma (IFNγ) expression in foals. Dev Comp Immunol. 2012 Mar;36(3):534-9. doi: 10.1016/j.dci.2011.09.009. Epub 2011 Nov 4. PMID: 22079897. 

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Liu C, Betancourt A, Cohen DA, Adams AA, Sun L, Horohov DW. Granzyme B-mRNA expression by equine lymphokine activated killer (LAK) cells is associated with the induction of apoptosis in target cells. Vet Immunol Immunopathol. 2011 Sep 15;143(1-2):108-15. doi: 10.1016/j.vetimm.2011.06.031. Epub 2011 Jul 13. PMID: 21802151.

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Sun L, Adams AA, Page AE, Betancourt A, Horohov DW. The effect of environment on interferon-gamma production in neonatal foals. Vet Immunol Immunopathol. 2011 Sep 15;143(1-2):170-5. doi: 10.1016/j.vetimm.2011.06.030. Epub 2011 Jun 28. PMID: 21767882.

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Page AE, Loynachan AT, Bryant U, Stills HF Jr, Adams AA, Gebhart CJ, Pusterla N, Horohov DW. Characterization of the interferon gamma response to Lawsonia intracellularis using an equine proliferative enteropathy challenge (EPE) model. Vet Immunol Immunopathol. 2011 Sep 15;143(1-2):55-65. doi: 10.1016/j.vetimm.2011.06.023. Epub 2011 Jun 13. PMID: 21719114.

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Liburt NR, Adams AA, Betancourt A, Horohov DW, McKeever KH. Exercise-induced increases in inflammatory cytokines in muscle and blood of horses. Equine Vet J Suppl. 2010 Nov;(38):280-8. doi: 10.1111/j.2042-3306.2010.00275.x. PMID: 21059019.

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Adams AA, Sturgill TL, Breathnach CC, Chambers TM, Siger L, Minke JM, Horohov DW. Humoral and cell-mediated immune responses of old horses following recombinant canarypox virus vaccination and subsequent challenge infection. Vet Immunol Immunopathol. 2011 Feb 15;139(2-4):128-40. doi: 10.1016/j.vetimm.2010.09.006. Epub 2010 Oct 7. PMID: 21035197.

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Horohov DW, Adams AA, Chambers TM. Immunosenescence of the equine immune system. J Comp Pathol. 2010 Jan;142 Suppl 1:S78-84. doi: 10.1016/j.jcpa.2009.10.007. Epub 2009 Nov 7. PMID: 19897209.

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Adams AA, Katepalli MP, Kohler K, Reedy SE, Stilz JP, Vick MM, Fitzgerald BP, Lawrence LM, Horohov DW. Effect of body condition, body weight and adiposity on inflammatory cytokine responses in old horses. Vet Immunol Immunopathol. 2009 Feb 15;127(3-4):286-94. doi: 10.1016/j.vetimm.2008.10.323. Epub 2008 Oct 31. PMID: 19097648.

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Adams AA, Breathnach CC, Katepalli MP, Kohler K, Horohov DW. Advanced age in horses affects divisional history of T cells and inflammatory cytokine production. Mech Ageing Dev. 2008 Nov;129(11):656-64. doi: 10.1016/j.mad.2008.09.004. Epub 2008 Sep 24. PMID: 18926847.

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Katepalli MP, Adams AA, Lear TL, Horohov DW. The effect of age and telomere length on immune function in the horse. Dev Comp Immunol. 2008;32(12):1409-15. doi: 10.1016/j.dci.2008.06.007. Epub 2008 Jul 9. PMID: 18619486.

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Vick MM, Adams AA, Murphy BA, Sessions DR, Horohov DW, Cook RF, Shelton BJ, Fitzgerald BP. Relationships among inflammatory cytokines, obesity, and insulin sensitivity in the horse. J Anim Sci. 2007 May;85(5):1144-55. doi: 10.2527/jas.2006-673. Epub 2007 Jan 30. PMID: 17264235.

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Breathnach CC, Sturgill-Wright T, Stiltner JL, Adams AA, Lunn DP, Horohov DW. Foals are interferon gamma-deficient at birth. Vet Immunol Immunopathol. 2006 Aug 15;112(3-4):199-209. doi: 10.1016/j.vetimm.2006.02.010. Epub 2006 Apr 18. PMID: 16621024.